Nanopore Helps Analytical Chemistry

with Porous Materials

by Our Hands

Group News

June, 2017  Ai-Na Meng successfully passed her master defense and will leave the group. We thank her contribution to the group and wish her a bright future!

June, 2017  Our paper in prophyrinic MOFs for efficient removal of bisphenol A has published in Sci. Rep.. Congratulations to Ai-Na Meng!

May, 2017  Our paper in 2-D MOF nanosheets as new enzyme inhibitor has published in J. Am. Chem. Soc.. Congratulations to Ming Xu!

May, 2017  Prof. Gu, Shi-Shu Yang and Ze-Rong Tao attended National Chromatography Conference at Lanzhou. Shi-Shu Yang won the Poster Award!

May, 2017  Prof. Gu and Ming Xu attended IUPAC International Conference for Analytical Science (ICAS) 2017 at Haikou. Gu won the Young Speaker Award! Ming Xu won the Poster Award!

Dec, 2016  Prof. Gu, Ming Xu, Mei-Yuan Shi and Yu-Jie Chang attended Life Science Analytical Chemistry Conference at Nanjing. Ming Xu won the Poster Award!

Nov, 2016  Prof. Gu, Ai-Na Meng, Shi-Shu Yang and Ze-Rong Tao attended East China Chromatography Conference at Xuzhou. Ai-Na Meng won the Poster Award!

Nov, 2016  Prof. Gu presented an invited talk at Young Analytical Scientist Forum in Chinese Academy of Agricultural Sciences. 

Oct, 2016  Our paper in new MALDI matrix has published in Chem. Comm.. Congratulations to Hai-Long and Yu-Jie!

Oct, 2015  Welcome Meng-Jun He to join our group as undergraduate student!

Sept, 2016  Prof. Z.-Y. Gu attended the MOF 2016 international conference at Long Beach, CA, United States.

Sept, 2016  Welcome Ming Xu, Ze-Rong Tao and Mei-Yuan Shi to join our group as master student and Jian-Xiang Wu as PhD student!

Sept, 2016  Welcome Hao Zhang and Chang-Song Zhou to join our group as adjunct research associate!

May, 2016  Our collaborative paper in MOF negative linear compressibility has published in Sci. Rep.. Congratulations to Prof. Hui Wang! 

Oct, 2015  Welcome Ling-Xiao Chai-Hu and Zi-Zhen Wang to join our group as undergraduate student!

Sept, 2015  Welcome Shi-Shu Yang and Yu-Jie Chang to join our group as master student!

Sept, 2015  Our lab moved to New Chemistry Building! 

Jan, 2015  Welcome Huan-Huan Chen, Ting Fan, Xin-Yu Chen and Hai-Xia Yu to join our group as undergraduate student!

Dec, 2014  Welcome Ai-Na Meng to join our group as master student!

Dec, 2014  Prof. Z.-Y. Gu joined the faculty of Chemistry as Jiangsu Distinguished Professor at Nanjing Normal University!



We build nothing from something.


We love sharp peaks!

2-D Nanosheets

We play bottom-up and top-down.

Mass Spectrometry

We help molecules fly.


We love sunshine.


Enzyme Inhibition

We mute proteins.

Group Leader


Zhi-Yuan Gu / 古志远

Jiangsu Distinguished Professor, 2014-2017
Young Elite Scientist, CAST, 2015-2017
Postdoc, Texas A&M University, 2011-2014

PhD, Nankai University, 2011

BS, Nankai University, 2006

Address: Nanjing Normal University (Xianlin Campus)
College of Chemistry and Materials Science
New Chemistry Building, Room 509
1st Wenyuan Rd, Nanjing, China, 210023

Phone: +86-25-85891952

Graduate Students


Jian-Xiang Wu / 吴建祥

Ph.D. Student (2016-2019)

MS, Shanghai University of Engineering Science, 2015

Research Interest: 2-D Nanosheets


Shi-Shu Yang / 杨世庶

Master Student (2015-2018)

BS, Zhengzhou Normal University, 2015

Research Interest: Protein Phosphorylation


Yu-Jie Chang / 常玉洁

Master Student (2015-2018)

BS, Shangqiu Normal University, 2015

Research Interest: 2-D Nanosheets


Ming Xu / 徐铭

Master Student (2016-2019)

BS, Nanjing Normal University, 2016

Research Interest: Enzyme Modulation


Ze-Rong Tao / 陶泽榕

Master Student (2016-2019)

BS, Jiangsu Second Normal University, 2015

Research Interest: Gas Chromatography


Mei-Yuan Shi / 石美媛

Master Student (2016-2019)

BS, Nanjing University, 2015

Research Interest: UCNP

Qi Zhang / 张琦

Master Student (2017-2020)

BS, Nanjing Normal University, 2017

Research Interest: Nanopore

Shu-Zhen Hou / 侯淑贞

Master Student (2017-2020)

BS, Shanxi University, 2017

Research Interest: Stable MOF synthesis

Jing Xiao / 肖静

Master Student (2017-2020)

BS, Guizhou Normal University, 2017

Research Interest: 2-D nanosheets

Undergraduate Students


Hai-Xia Yu / 于海霞

Undergraduate Student (2014-2018)


Huan-Huan Chen / 陈欢欢

Undergraduate Student (2014-2018)


Xin-Yu Chen / 陈心瑜

Undergraduate Student (2014-2018)


Meng-Jun He / 何孟君

Undergraduate Student (2015-2019)

Research Associates


Hao Zhang / 张浩

Adjunct Research Associate (2016- )
PhD, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences, 2016

Current Position: College of Science, China Pharmaceutical University

Research Interest: MOF Fluorescence


Chang-Song Zhou / 周长松

Adjunct Postdoc Associate (2016- )
PhD, Huazhong University of Science and Technology, 2016

Current Position: School of Energy and Mechanical Engineering, Nanjing Normal University

Research Interest: Degradation of Pollutants

Group Alumni

Ai-Na Meng / 孟爱娜

Master Student

Current Job: Qianhuang International Middle School

MS, Nanjing Normal University, 2017

BS, Huaibei Normal University, 2014

Ling-Xiao Chaihu / 柴胡玲潇

Undergraduate Student

Current Position: MS student, NJNU

BS, Nanjing Normal University, 2017

Zi-Zhen Wang / 王兹臻

Undergraduate Student

Current Position: MS Student, CCNU

BS, Nanjing Normal University, 2017


27. Meng, A.-N.; Chaihu, L.-X.; Chen, H.-H.; Gu, Z.-Y.*Ultrahigh adsorption and singlet-oxygen mediated degradation for efficient synergetic removal of bisphenol A by a stable zirconium-porphyrin metal-organic framework, Sci. Rep., 2017, in press.

26. Xu, M.; Yuan, S. (equal contribution); Chen, X.-Y.; Chang, Y.-J.; Day, G.;  Gu, Z.-Y.*Zhou, H.-C.*Two-Dimensional Metal-Organic Framework Nanosheets as an Enzyme Inhibitor: Modulation of the α-Chymotrypsin Activity, J. Am. Chem. Soc., 2017, 139, 8312-8319. [Link]

25. Liu, H.-L.†; Chang, Y.-J. (equal contribution); Fan, T.; Gu, Z.-Y.*Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations, Chem. Commun., 2016, 52, 12984-12987. [Link]

24. Wang, H.*; Feng, M.; Wang, Y.-F.; Gu, Z.-Y.*, H3O+ tetrahedron induction in large negative linear compressibility, Sci. Rep., 2016, 6, 26015. [Link]

Before NJNU

23. Gu, Z.-Y.; Yang, C.-X.; Chang, N.; Yan, X.-P.*, “Metal-Organic Frameworks for Analytical Chemistry: From Sample Collection to Chromatographic Separation”, Acc. Chem. Res., 2012, 45, 734-745. [Link] (Highlighted in Chemistry World, [Link])

22. Gu, Z.-Y.; Yan, X.-P.*, “Metal-Organic Framework MIL-101 for High-Resolution Gas Chromatographic Separation of Xylene Isomers and Ethylbenzene”, Angew. Chem. Int. Ed., 2010, 49, 1477-1480. [Link]

21. Feng, D.; Gu, Z.-Y. (†equal contribution); Li, J.-R.; Jiang, H.-L.; Wei, Z.; Zhou, H.-C*, “Zirconium-Metalloporphyrin PCN-222: Mesoporous Metal-Organic Frameworks with Ultrahigh Stability as A Biomimetic Catalyst”, Angew. Chem. Int. Ed., 2012, 51, 10307-10310. [Link] (VIP and Cover feature, Highlighted in C&EN, [Link]).

20. Wei, Z.; Gu, Z.-Y. (equal contribution); Arvapally, R.; Chen, Y.-P.; McDougald, R.; Yakovenko, A.; Feng, D.; Omary, M.; Zhou, H.-C.*, “Rigidifying Fluorescent Linkers by MOF Formation for Fluorescence Blue Shift and Quantum Yield Enhancement”, J. Am. Chem. Soc. 2014, 136, 8269-8276. [Link] (Highlited in Argonne National Lab, United States) [Link] 

19. Feng, D.; Gu, Z.-Y. (equal contribution); Chen, Y.-P.; Park, J.; Wei, Z.; Sun, Y.; Bosch, M.; Yuan, S.; Zhou, H.-C.*, “A Highly Stable Porphyrinic Zirconium Metal-Organic Framework with  shp-a Topology”, J. Am. Chem. Soc. 2014, 136, 17714-17717[Link] 

18. Gu, Z.-Y.; Wang, G.; Yan, X.-P.*, “MOF-5 Metal-Organic Framework as Sorbent for In-Field Sampling and Preconcentration in Combination with Thermal Desorption GC-MS for Determination of Atmospheric Formaldehyde”, Anal. Chem., 2010, 82, 1365–1370. [Link]

17. Gu, Z.-Y.; Jiang, J.-Q.; Yan, X.-P.*, “Fabrication of Isoreticular Metal-Organic Framework Coated Capillary Columns for High-Resolution Gas Chromatographic Separation of Persistent Organic Pollutants”, Anal. Chem., 2011, 83, 5093-5100. [Link]

16. Gu, Z.-Y.; Chen, Y.-J.; Jiang, J.-Q.; Yan, X.-P.*, “Metal-Organic Frameworks for Efficient Enrichment of Peptides with Simultaneous Exclusion of Proteins from Complex Biological Samples”, Chem. Comm., 2011, 47, 4787-4789. [Link]

15. Gu, Z.-Y.; Jiang, D.-Q.; Wang, H.-F.; Cui, X.-Y.; Yan, X.-P.*, “Adsorption and Separation of Xylene Isomers and Ethylbenzene on Two Zn-Terephthalate Metal-Organic Frameworks”, J. Phys. Chem. C, 2010, 114, 311-316. [Link]

14.Gu, Z.-Y., Park, J., Raiff, A., Wei, Z., Zhou, H.-C.*, “Metal-Organic Frameworks as Biomimetic Catalysts”, ChemCatChem 2014, 6, 67-75. [Link]

13. Zhang, M.; Gu, Z.-Y.; Bosch, M.; Perry, Z.; Zhou, H.-C.*, “Biomimicry in Metal-Organic Materials”, Coord. Chem. Rev., 2015, 293-294, 327-356.

12. Chang, N.; Gu, Z.-Y.; Yan, X.-P.*, “Zeolitic Imidazolate Framework-8 Nanocrystals Coated Capillary for Molecular Sieving of Branched Alkanes from Linear Alkanes along with High-Resolution Chromatographic Separation of Linear Alkanes”, J. Am. Chem. Soc., 2010, 132, 13645-13647.

11. Cui, X.-Y.; Gu, Z.-Y.; Jiang, D.-Q.; Li, Y.; Wang, H.-F.; Yan, X.-P.*, “In Situ Hydrothermal Growth of Metal-Organic Framework MOF-199 Films on Stainless Steel Fiber for Solid-Phase Microextraction of Gaseous Benzene Homologues”, Anal. Chem., 2009, 81, 9771-9777. (Highlighted in Separation Science)

10. Chang, N.; Gu, Z.-Y.; Wang, H.-F.; Yan, X.-P.*, “Metal-Organic Frameworks Based Tandem Molecular Sieve as a Dual Platform for Selective Extraction and High-Performance Chromatographic Separation of Volatile n-Alkanes in Complex Matrices”, Anal. Chem., 2011, 83, 7094-7101. (Highlighted in separationNOW)

9. Lu, W., Wei, Z., Gu, Z.-Y., Liu, T.-F., Park, J., Park, J., Tian, J., Zhang, M., Zhang, Q., Gentle, T., Bosch, M., Zhou, H.-C.*, “Tuning the structure and function of metal–organic frameworks via linker design”, Chem. Soc. Rev. 2014, 43, 5561-5593.

8. Huang, C.-Y.; Song, M.; Gu, Z.-Y.; Wang, H.-F.; Yan, X.-P.*, “Adsorption Characteristic of Metal-Organic Framework MIL-101 for Volatile Organic Compounds Probed by Quartz Crystal Microbalance in Combination with Dubinin-Astakhov Equation”, Environ. Sci. Technol. 2011, 45, 4490-4496.

7. Wang, J.-X.; Jiang, D.-Q.; Gu, Z.-Y.; Yan, X.-P.*, “Multiwalled Carbon Nanotubes Coated Fibers for Solid-Phase Microextraction of Polybrominated Diphenyl Ethers in Water and Milk samples before Gas Chromatography with Electron-Capture Detection”, J. Chromatogr. A, 2006, 1137, 8-14.

6. Sun, L.-B; Li, J.-R.; Lu, W.; Gu, Z.-Y.; Luo, Z.; Zhou, H.-C*, “Metal-Organic Polyhedra Confinement in Silica Nanopores”, J. Am. Chem. Soc., 2012, 134, 15923-15928.

5. Jiang, H.-L.; Feng, D.; Wang, K.; Gu, Z.-Y.; Wei, Z.; Chen, Y.-P.; Zhou, H.-C.*, “An Exceptionally Stable, Porphyrinic Zr Metal-Organic Framework Exhibiting pH-Dependent Fluorescence”, J. Am. Chem. Soc. 2013, 135, 13934–13938.

4. Feng, D.; Chung, W.-C.; Wei, Z.; Gu, Z.-Y.; Jiang, H.-L.; Darensbourg D.; Zhou, H.-C.*, “Construction of an Ultrastable Porphyrin Zr Metal-Organic Framework through Linker Elimination”, J. Am. Chem. Soc. 2013, 135, 17105–17110.

3. Feng, D.; Jiang, H.-L.; Chen, Y.-P.; Gu, Z.-Y.; Wei, Z.; Zhou, H.-C.*, “Metal-Organic Frameworks Based on Previously Unknown Zr8/Hf8 Cubic Clusters”, Inorg. Chem.2013, 52, 12661–12667.

2. Feng, D.; Liu, T.-F.; Su, J.; Bosch, M.; Wei, Z.; Wan, W.; Chen, Y.-P.; Wang, X.; Wang, K.; Lian, X.; Gu, Z.-Y.; Park, J.; Yuan, D.; Zou, X.; Zhou, H.-C.*, “Stable Metal-Organic Frameworks Containing Single-Molecule Traps for Enzyme Encapsulation”, Nature Commun. 2015, 6:5979 doi: 10.1038/ncomms6979.

1. Wang, X.; Lu, W.; Gu. Z.-Y.; Wei, Z.; Zhou, H.-C.*,Topology-guided design of an anionic bor-network for photocatalytic [Ru(bpy)3]2+ encapsulation”, Chem. Comm. 2016,52, 1926–1929.


Instrumental Analysis


for 3rd-year Undergraduate 

(2016 Autumn, 2017 Autumn)

Instrumental Analysis Experiments


for 3rd-year Undergraduate 

(2016 Spring)

Research Frontiers in Analytical Chemistry


for 1rd-year master student 

(2015 Autumn, 2017 Spring, 2017 Autumn)

Chromatographic Experiments


for 3rd-year Undergraduate 

(2016 Spring, 2017 Spring)